While identifying and treating the causes of pastoral burnout is complex and includes assessments of mental, spiritual, and physical health, I believe that 2 Corinthians 4 provides unique theological encouragement for endurance in ministry, highlighting the important connection between mind and heart. Paul’s usage of “therefore” (v. 1) and “so” (v. 16) indicate the motivations, or reasons, for Paul’s endurance in ministry. Further, Paul’s usage of “but” (v. 2, alla) introduces a section describing his ministry as a “sharp contrast” to a ministry characterized as having lost “heart.” Thus, Paul’s language in chapter four provides both reasons for perseverance as well as evidences of perseverance. While much more could be gleaned from Paul’s letter to the church at Corinth, the scope of this paper will be limited to 4:1-16, those truths sandwiched between Paul’s two declarations that “we do not lose heart.” This paper will briefly introduce seven theological truths that offer encouragement for endurance in gospel ministry along with corresponding opportunities for personal reflection.